| 1. Journée | 12.03.2021 | Real Tomayapo | - | Always Ready | 1:0 |  |
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| 2. Journée | 14.03.2021 | Always Ready | - | Club San José | 5:0 | ||||
| 3. Journée | 03.04.2021 | Real Santa Cruz | - | Always Ready | 2:3 | ||||
| 4. Journée | 10.04.2021 | Always Ready | - | Nacional Potosí | 1:1 | |
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| 18. Journée | 14.09.2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
| 19. Journée | 19.09.2021 | Nacional Potosí | - | Always Ready | 0:2 | ||||
| 20. Journée | 23.09.2021 | Always Ready | - | Oriente Petrolero | 2:0 | ||||
| 21. Journée | 27.09.2021 | The Strongest | - | Always Ready | 1:1 | ||||
| 23. Journée | 24.10.2021 | Atlético Palmaflor | - | Always Ready | 0:1 | ||||
| 24. Journée | 27.10.2021 | Always Ready | - | Independiente Petrolero | 2:2 | |
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| 25. Journée | 31.10.2021 | Always Ready | - | Royal Pari | 2:1 | |
Panama