| 1. Journée | 12.09.2021 | Boston River | - | Montevideo Wanderers | 1:3 |  |
|||
| 4. Journée | 03.10.2021 | Montevideo City Torque | - | Boston River | 4:3 | ||||
| 5. Journée | 10.10.2021 | Boston River | - | Villa Española | 1:0 | ||||
| 6. Journée | 16.10.2021 | Nacional | - | Boston River | 3:2 |  |
|||
| 7. Journée | 21.10.2021 | Boston River | - | Cerrito | 3:2 | ||||
| 8. Journée | 24.10.2021 | Liverpool | - | Boston River | 2:2 | ||||
| 9. Journée | 30.10.2021 | Boston River | - | River Plate | 1:2 | |
|||
| 11. Journée | 08.11.2021 | Boston River | - | Progreso | 0:0 | |
|||
| 12. Journée | 14.11.2021 | Sud América | - | Boston River | 1:2 | |
|||
| 13. Journée | 22.11.2021 | Boston River | - | Plaza Colonia | 2:0 |  |
|||
| 15. Journée | 04.12.2021 | Boston River | - | Deportivo Maldonado | 2:1 |
Uruguay