| 5. Journée | 31.07.2022 | El Paso Locomotive | - | Louisville City FC | 0:1 | ||||
| 6. Journée | 28.08.2022 | Miami FC | - | Louisville City FC | 1:0 | ||||
| 7. Journée | 04.09.2022 | Louisville City FC | - | Sacramento Republic | 3:1 |  |
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| 7. Journée | 08.09.2022 | FC Tulsa | - | Louisville City FC | 2:2 | ||||
| 7. Journée | 11.09.2022 | Pittsburgh Riverhounds | - | Louisville City FC | 0:0 | ||||
| 7. Journée | 18.09.2022 | Louisville City FC | - | Loudoun United | 4:2 | ||||
| 8. Journée | 02.10.2022 | Rio Grande Valley FC | - | Louisville City FC | 0:1 | ||||
| 8. Journée | 06.10.2022 | Louisville City FC | - | Detroit City FC | 2:1 | ||||
| 8. Journée | 16.10.2022 | Louisville City FC | - | Hartford Athletic | 2:1 |
États-Unis