| 1. Journée | 20.01.2022 | Lobos UPNFM | - | Vida | 3:0 | ||||
| 2. Journée | 23.01.2022 | Honduras Progreso | - | Lobos UPNFM | 1:2 |  |
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| 4. Journée | 10.02.2022 | Lobos UPNFM | - | Platense | 1:2 | ||||
| 7. Journée | 27.02.2022 | Lobos UPNFM | - | Olimpia | 0:3 |  |
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| 8. Journée | 03.03.2022 | Real España | - | Lobos UPNFM | 1:0 | |
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| 9. Journée | 07.03.2022 | Marathón | - | Lobos UPNFM | 4:1 | ||||
| 11. Journée | 20.03.2022 | Lobos UPNFM | - | Honduras Progreso | 2:2 | ||||
| 14. Journée | 11.04.2022 | Motagua | - | Lobos UPNFM | 2:0 | |
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| 15. Journée | 14.04.2022 | Lobos UPNFM | - | Real España | 0:2 | |
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| 17. Journée | 25.04.2022 | Olimpia | - | Lobos UPNFM | 0:1 | ||||
| 18. Journée | 01.05.2022 | Lobos UPNFM | - | Marathón | 1:2 |  |
Honduras