| Zona B | 21.02.2021 | Deportivo Guastatoya | - | Sanarate | 5:1 | ||||
| Zona B | 27.02.2021 | CSD Municipal | - | Deportivo Guastatoya | 0:1 | ||||
| Zona B | 03.03.2021 | Deportivo Guastatoya | - | Achuapa | 3:0 |  |
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| Zona B | 07.03.2021 | Sacachispas | - | Deportivo Guastatoya | 0:1 | ||||
| Zona B | 10.03.2021 | Deportivo Guastatoya | - | Cobán Imperial | 1:1 | ||||
| Zona B | 10.04.2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
| Demi-finales Groupe A | 14.04.2021 | Deportivo Guastatoya | - | Santa Lucía | 1:1 |  |
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| Demi-finales Groupe A | 25.04.2021 | Antigua GFC | - | Deportivo Guastatoya | 0:0 | ||||
| Demi-finales Groupe A | 02.05.2021 | Iztapa | - | Deportivo Guastatoya | 2:2 | |
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| Demi-finales | 16.05.2021 | Deportivo Guastatoya | - | Santa Lucía | 1:2 |
Colombie