| 1. Journée | 15.08.2021 | Southampton FC U23 | - | Norwich City U23 | 0:3 |  |
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| 2. Journée | 23.08.2021 | Nottingham Forest U23 | - | Southampton FC U23 | 0:0 | |
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| 3. Journée | 29.08.2021 | Middlesbrough FC U23 | - | Southampton FC U23 | 2:1 | ||||
| 4. Journée | 10.09.2021 | Fulham FC U23 | - | Southampton FC U23 | 3:0 | ||||
| 5. Journée | 19.09.2021 | Southampton FC U23 | - | Burnley FC U23 | 0:2 | |
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| 6. Journée | 27.09.2021 | Birmingham City U23 | - | Southampton FC U23 | 3:2 | ||||
| 7. Journée | 01.10.2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
| 8. Journée | 18.10.2021 | Wolverhampton Wanderers U23 | - | Southampton FC U23 | 0:1 | ||||
| 9. Journée | 25.10.2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 10. Journée | 31.10.2021 | Southampton FC U23 | - | Aston Villa U23 | 4:0 | |
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| 11. Journée | 05.11.2021 | Southampton FC U23 | - | Newcastle United U23 | 5:0 |  |
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| 12. Journée | 21.11.2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | |
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| 13. Journée | 28.11.2021 | Southampton FC U23 | - | West Bromwich Albion U23 | 3:1 | ||||
| 14. Journée | 06.12.2021 | Stoke City U23 | - | Southampton FC U23 | 3:0 | ||||
| 15. Journée | 17.12.2021 | Norwich City U23 | - | Southampton FC U23 | 4:3 |
Cameroun