| 1. Journée | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 |  |
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| 2. Journée | 21.01.2021 | Montevideo Wanderers | - | Danubio | 2:0 | |
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| 3. Journée | 31.01.2021 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 4. Journée | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 5. Journée | 06.02.2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:1 | ||||
| 6. Journée | 10.02.2021 | Montevideo Wanderers | - | Rentistas | 3:2 | ||||
| 7. Journée | 13.02.2021 | Cerro Largo | - | Montevideo Wanderers | 1:3 |  |
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| 8. Journée | 17.02.2021 | Liverpool | - | Montevideo Wanderers | 2:1 | ||||
| 9. Journée | 21.02.2021 | Montevideo Wanderers | - | Peñarol | 0:1 | ||||
| 11. Journée | 06.03.2021 | Montevideo Wanderers | - | Montevideo City Torque | 2:8 | ||||
| 12. Journée | 12.03.2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 | ||||
| 13. Journée | 21.03.2021 | Montevideo Wanderers | - | Progreso | 3:0 | ||||
| 14. Journée | 25.03.2021 | Fénix | - | Montevideo Wanderers | 3:3 | ||||
| 15. Journée | 29.03.2021 | Montevideo Wanderers | - | CA Cerro | 1:1 |
Uruguay