| 1. Journée | 16.02.2020 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | ||||
| 2. Journée | 23.02.2020 | Defensor Sporting | - | Peñarol | 2:1 | ||||
| 5. Journée | 14.08.2020 | Plaza Colonia | - | Defensor Sporting | 2:0 |  |
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| 6. Journée | 19.08.2020 | Defensor Sporting | - | Progreso | 2:1 |  |
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| 7. Journée | 23.08.2020 | Fénix | - | Defensor Sporting | 5:0 | ||||
| 9. Journée | 30.08.2020 | Liverpool | - | Defensor Sporting | 1:2 | |
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| 10. Journée | 06.09.2020 | Danubio | - | Defensor Sporting | 0:0 | |
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| 11. Journée | 11.09.2020 | Defensor Sporting | - | Nacional | 1:1 | ||||
| 12. Journée | 13.09.2020 | Boston River | - | Defensor Sporting | 1:1 | |
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| 13. Journée | 20.09.2020 | Defensor Sporting | - | Deportivo Maldonado | 4:2 | |
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| 14. Journée | 07.10.2020 | Rentistas | - | Defensor Sporting | 2:0 | |
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| 15. Journée | 11.10.2020 | Defensor Sporting | - | Cerro Largo | 2:0 |
Uruguay