| 1. Journée | 21.07.2018 | Boston River | - | River Plate | 2:3 |  |
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| 2. Journée | 29.07.2018 | Montevideo Wanderers | - | Boston River | 3:1 | ||||
| 3. Journée | 05.08.2018 | Boston River | - | Liverpool | 1:0 | |
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| 5. Journée | 19.08.2018 | Boston River | - | CA Cerro | 2:3 | |
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| 6. Journée | 26.08.2018 | Boston River | - | Peñarol | 1:2 | ||||
| 7. Journée | 02.09.2018 | Atenas | - | Boston River | 1:0 | ||||
| 8. Journée | 09.09.2018 | Boston River | - | Danubio | 0:0 | ||||
| 9. Journée | 15.09.2018 | Torque | - | Boston River | 3:2 | |
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| 10. Journée | 23.09.2018 | Boston River | - | Rampla Juniors | 0:0 | ||||
| 11. Journée | 07.10.2018 | Fénix | - | Boston River | 2:1 | |
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| 13. Journée | 21.10.2018 | Progreso | - | Boston River | 1:0 | |
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| 14. Journée | 28.10.2018 | Boston River | - | Defensor Sporting | 3:1 | |
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| 15. Journée | 04.11.2018 | Racing | - | Boston River | 3:0 |  |
Uruguay