| 12. Journée | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 |  |
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| 13. Journée | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | |
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| 14. Journée | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 17. Journée | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 18. Journée | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 |  |
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| 21. Journée | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 |
Uruguay