| 1. Journée | 06.02.2016 | Fénix | - | River Plate | 1:1 |  |
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| 2. Journée | 13.02.2016 | River Plate | - | Nacional | 0:3 | |
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| 4. Journée | 27.02.2016 | River Plate | - | Montevideo Wanderers | 1:1 | |
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| 5. Journée | 06.03.2016 | Racing | - | River Plate | 0:1 | ||||
| 7. Journée | 03.04.2016 | Peñarol | - | River Plate | 0:2 | ||||
| 8. Journée | 10.04.2016 | River Plate | - | Juventud de Las Piedras | 0:0 | |
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| 9. Journée | 24.04.2016 | Danubio | - | River Plate | 0:3 | ||||
| 10. Journée | 30.04.2016 | River Plate | - | CA Cerro | 3:1 | |
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| 14. Journée | 29.05.2016 | River Plate | - | Defensor Sporting | 1:2 | ||||
| 15. Journée | 05.06.2016 | Villa Teresa | - | River Plate | 2:0 |
Uruguay
Italie