| 1. Journée | 22.01.2019 | San Lorenzo | - | River Plate | 1:0 | ||||
| 2. Journée | 29.01.2019 | River Plate | - | Sportivo Luqueño | 2:1 | ||||
| 3. Journée | 02.02.2019 | Deportivo Santaní | - | River Plate | 1:1 |  |
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| 4. Journée | 05.02.2019 | River Plate | - | Sol de América | 1:0 | ||||
| 6. Journée | 17.02.2019 | River Plate | - | Libertad | 1:1 | ||||
| 7. Journée | 23.02.2019 | Deportivo Capiatá | - | River Plate | 3:3 | ||||
| 8. Journée | 27.02.2019 | River Plate | - | General Díaz | 3:2 | |
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| 9. Journée | 04.03.2019 | Guaraní | - | River Plate | 2:1 | |
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| 10. Journée | 09.03.2019 | Club Olimpia | - | River Plate | 0:0 | ||||
| 11. Journée | 16.03.2019 | River Plate | - | Club Nacional | 1:1 | ||||
| 12. Journée | 24.03.2019 | River Plate | - | San Lorenzo | 2:1 | |
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| 13. Journée | 01.04.2019 | Sportivo Luqueño | - | River Plate | 3:1 | |
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| 15. Journée | 09.04.2019 | Sol de América | - | River Plate | 0:1 | ||||
| 17. Journée | 21.04.2019 | Libertad | - | River Plate | 2:1 | ||||
| 18. Journée | 28.04.2019 | River Plate | - | Deportivo Capiatá | 1:0 | ||||
| 19. Journée | 01.05.2019 | General Díaz | - | River Plate | 0:1 | ||||
| 22. Journée | 19.05.2019 | Club Nacional | - | River Plate | 0:0 |
Paraguay