| 1. Journée | 20.03.2022 | Louisville City FC | - | Miami FC | 2:0 | ||||
| 1. Journée | 24.03.2022 | New York RB II | - | Louisville City FC | 0:2 | ||||
| 2. Journée | 03.04.2022 | Birmingham Legion | - | Louisville City FC | 0:0 | ||||
| 2. Journée | 23.04.2022 | Charleston Battery | - | Louisville City FC | 1:1 | ||||
| 3. Journée | 01.05.2022 | Louisville City FC | - | Pittsburgh Riverhounds | 2:0 | ||||
| 3. Journée | 05.05.2022 | Atlanta United II | - | Louisville City FC | 0:4 | ||||
| 4. Journée | 25.06.2022 | Hartford Athletic | - | Louisville City FC | 0:2 | ||||
| 6. Journée | 07.08.2022 | Louisville City FC | - | Charleston Battery | 4:1 | ||||
| 6. Journée | 21.08.2022 | Detroit City FC | - | Louisville City FC | 0:1 | ||||
| 6. Journée | 28.08.2022 | Miami FC | - | Louisville City FC | 1:0 | ||||
| 7. Journée | 01.09.2022 | Indy Eleven | - | Louisville City FC | 2:1 |  |
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| 8. Journée | 02.10.2022 | Rio Grande Valley FC | - | Louisville City FC | 0:1 | |
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| 8. Journée | 16.10.2022 | Louisville City FC | - | Hartford Athletic | 2:1 |
États-Unis