| 5. Journée | 22.08.2021 | Comunicaciones | - | Cobán Imperial | 2:2 | ||||
| 6. Journée | 25.08.2021 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
| 7. Journée | 29.08.2021 | Cobán Imperial | - | Antigua GFC | 0:2 |  |
|||
| 9. Journée | 11.09.2021 | Cobán Imperial | - | Santa Lucía | 0:1 | |
|||
| 8. Journée | 13.10.2021 | Deportivo Guastatoya | - | Cobán Imperial | 0:1 | ||||
| 15. Journée | 23.10.2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 16. Journée | 27.10.2021 | Cobán Imperial | - | Comunicaciones | 1:2 | ||||
| 17. Journée | 31.10.2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 18. Journée | 07.11.2021 | Antigua GFC | - | Cobán Imperial | 2:1 | |
|||
| 19. Journée | 13.11.2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
| 20. Journée | 20.11.2021 | Santa Lucía | - | Cobán Imperial | 2:2 |
Guatemala