| 2. Journée | 22.08.2015 | Racing | - | Defensor Sporting | 0:2 | ||||
| 3. Journée | 30.08.2015 | Defensor Sporting | - | Peñarol | 3:1 |  |
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| 5. Journée | 12.09.2015 | Defensor Sporting | - | Rentistas | 2:0 | |
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| 6. Journée | 19.09.2015 | Liverpool | - | Defensor Sporting | 2:1 |  |
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| 8. Journée | 04.10.2015 | Nacional | - | Defensor Sporting | 4:0 | ||||
| 9. Journée | 17.10.2015 | Defensor Sporting | - | Montevideo Wanderers | 2:3 | |
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| 10. Journée | 24.10.2015 | Plaza Colonia | - | Defensor Sporting | 0:0 | ||||
| 11. Journée | 01.11.2015 | Defensor Sporting | - | Juventud de Las Piedras | 4:1 | ||||
| 12. Journée | 07.11.2015 | CA Cerro | - | Defensor Sporting | 2:3 | ||||
| 13. Journée | 21.11.2015 | Defensor Sporting | - | El Tanque Sisley | 2:2 | ||||
| 15. Journée | 05.12.2015 | Fénix | - | Defensor Sporting | 3:0 |
Uruguay