| 1. Journée | 08.01.2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 0:4 | ||||
| 2. Journée | 16.01.2022 | Atlético San Luis [] | - | Mazatlán FC [] | 2:1 | ||||
| 4. Journée | 29.01.2022 | CF Monterrey [] | - | Mazatlán FC [] | 3:2 |  |
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| 5. Journée | 05.02.2022 | Mazatlán FC [] | - | UANL Tigres [] | 1:2 | ||||
| 6. Journée | 12.02.2022 | Mazatlán FC [] | - | Club Tijuana [] | 1:3 | ||||
| 7. Journée | 19.02.2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 2:0 | ||||
| 8. Journée | 26.02.2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
| 9. Journée | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
| 10. Journée | 12.03.2022 | Mazatlán FC [] | - | CF Monterrey [] | 1:3 | ||||
| 11. Journée | 19.03.2022 | UANL Tigres [] | - | Mazatlán FC [] | 5:0 | |
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| 12. Journée | 26.03.2022 | Santos Laguna [] | - | Mazatlán FC [] | 3:2 |  |
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| 13. Journée | 02.04.2022 | Mazatlán FC [] | - | Club León [] | 0:3 | ||||
| 14. Journée | 09.04.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 1:2 | |
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| 15. Journée | 16.04.2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 5:1 | ||||
| 16. Journée | 23.04.2022 | Mazatlán FC [] | - | Atlético San Luis [] | 2:0 | |
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| 17. Journée | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 | |
Mexique