| 3. Journée | 17.08.2021 | Port Vale FC | - | Carlisle United | 0:0 | ||||
| 5. Journée | 28.08.2021 | Hartlepool United | - | Carlisle United | 2:1 | ||||
| 7. Journée | 11.09.2021 | Crawley Town | - | Carlisle United | 2:1 | ||||
| 8. Journée | 18.09.2021 | Carlisle United | - | Scunthorpe United | 2:2 | ||||
| 9. Journée | 25.09.2021 | Sutton United | - | Carlisle United | 4:0 | ||||
| 10. Journée | 02.10.2021 | Carlisle United | - | Forest Green Rovers | 0:2 | ||||
| 11. Journée | 09.10.2021 | Bristol Rovers | - | Carlisle United | 3:0 | ||||
| 13. Journée | 19.10.2021 | Newport County | - | Carlisle United | 2:2 | ||||
| 14. Journée | 23.10.2021 | Carlisle United | - | Oldham Athletic | 0:0 | ||||
| 16. Journée | 13.11.2021 | Carlisle United | - | Barrow AFC | 0:0 | ||||
| 17. Journée | 20.11.2021 | Exeter City | - | Carlisle United | 2:1 | ||||
| 18. Journée | 23.11.2021 | Carlisle United | - | Harrogate Town | 0:2 | ||||
| 19. Journée | 27.11.2021 | Carlisle United | - | Walsall FC | 1:0 | ||||
| 20. Journée | 07.12.2021 | Mansfield Town | - | Carlisle United | 1:0 |
Angleterre