| 4. Journée | 16.03.2025 | St. Louis City SC | - | Seattle Sounders | 1:0 | ||||
| 5. Journée | 23.03.2025 | Philadelphia Union | - | St. Louis City SC | 1:0 | ||||
| 6. Journée | 30.03.2025 | St. Louis City SC | - | Austin FC | 0:1 | ||||
| 7. Journée | 06.04.2025 | Sporting Kansas City | - | St. Louis City SC | 2:0 | ||||
| 8. Journée | 14.04.2025 | St. Louis City SC | - | Columbus Crew | 1:2 | ||||
| 9. Journée | 20.04.2025 | St. Louis City SC | - | Vancouver Whitecaps | 0:0 | ||||
| 10. Journée | 28.04.2025 | Los Angeles FC | - | St. Louis City SC | 2:2 | ||||
| 11. Journée | 04.05.2025 | Seattle Sounders | - | St. Louis City SC | 4:1 | ||||
| 12. Journée | 11.05.2025 | St. Louis City SC | - | San Diego FC | 1:2 | ||||
| 20. Journée | 29.06.2025 | Houston Dynamo | - | St. Louis City SC | 1:0 |  |
Allemagne