| 2. Journée | 13.02.2022 | Real Santa Cruz | - | CD Guabirá | 2:2 |  |
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| 3. Journée | 18.02.2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 4. Journée | 26.02.2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 5. Journée | 06.03.2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
| 6. Journée | 12.03.2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
| 9. Journée | 16.04.2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 | ||||
| 11. Journée | 24.04.2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 |  |
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| 12. Journée | 30.04.2022 | The Strongest | - | Real Santa Cruz | 1:1 | ||||
| 15. Journée | 14.05.2022 | Oriente Petrolero | - | Real Santa Cruz | 1:2 |
Bolivie