| 1. Journée | 25.07.2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Journée | 01.08.2021 | Vorskla Poltava | - | Rukh Lviv | 2:0 | ||||
| 3. Journée | 07.08.2021 | Rukh Lviv | - | NK Veres | 2:1 |  |
|||
| 4. Journée | 15.08.2021 | Kolos Kovalivka | - | Rukh Lviv | 1:1 | |
|||
| 5. Journée | 21.08.2021 | SK Dnipro-1 | - | Rukh Lviv | 2:0 | ||||
| 6. Journée | 29.08.2021 | Rukh Lviv | - | FK Lviv | 1:0 |  |
|||
| 7. Journée | 11.09.2021 | Rukh Lviv | - | Zorya Lugansk | 1:1 | |
|||
| 8. Journée | 17.09.2021 | Desna Chernigov | - | Rukh Lviv | 1:0 | |
|||
| 9. Journée | 25.09.2021 | Rukh Lviv | - | Dinamo Kiev | 0:2 | ||||
| 10. Journée | 01.10.2021 | FK Mariupol | - | Rukh Lviv | 0:2 | ||||
| 13. Journée | 31.10.2021 | Rukh Lviv | - | FK Oleksandriya | 0:0 | ||||
| 14. Journée | 06.11.2021 | Chernomorets Odessa | - | Rukh Lviv | 4:3 | ||||
| 16. Journée | 28.11.2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 | |
Ukraine