| 7. Journée | 05.09.2010 | D.C. United | - | Columbus Crew | 0:1 | ||||
| 7. Journée | 12.09.2010 | Los Angeles Galaxy | - | Columbus Crew | 3:1 |  |
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| 7. Journée | 19.09.2010 | Columbus Crew | - | Seattle Sounders | 0:4 | ||||
| 7. Journée | 26.09.2010 | New England Revolution | - | Columbus Crew | 2:2 | ||||
| 8. Journée | 03.10.2010 | Columbus Crew | - | San Jose Earthquakes | 0:0 | ||||
| 8. Journée | 09.10.2010 | Chicago Fire | - | Columbus Crew | 2:0 | ||||
| 8. Journée | 16.10.2010 | Toronto FC | - | Columbus Crew | 2:2 | ||||
| 8. Journée | 24.10.2010 | Columbus Crew | - | Philadelphia Union | 3:1 | |
Pérou