| 1. Journée | 30.07.2022 | Plaza Colonia | - | Boston River | 1:1 |  |
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| 2. Journée | 07.08.2022 | Cerrito | - | Boston River | 0:3 | ||||
| 3. Journée | 12.08.2022 | Boston River | - | River Plate | 1:2 | ||||
| 6. Journée | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Journée | 27.08.2022 | Boston River | - | Fénix | 1:1 | ||||
| 4. Journée | 04.09.2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 7. Journée | 10.09.2022 | Boston River | - | Albion | 1:0 | ||||
| 8. Journée | 15.09.2022 | Nacional | - | Boston River | 1:0 | ||||
| 9. Journée | 19.09.2022 | Boston River | - | Danubio | 0:1 |
Uruguay