| 9. Journée | 18.07.2021 | The Strongest | - | CD Guabirá | 2:1 | ||||
| 11. Journée | 25.07.2021 | The Strongest | - | Bolívar | 3:1 |  |
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| 12. Journée | 31.07.2021 | Club Aurora | - | The Strongest | 0:1 | |
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| 14. Journée | 07.08.2021 | Club San José | - | The Strongest | 0:1 | |
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| 15. Journée | 15.08.2021 | The Strongest | - | Real Santa Cruz | 1:2 | ||||
| 19. Journée | 19.09.2021 | The Strongest | - | Jorge Wilstermann | 3:1 | ||||
| 20. Journée | 23.09.2021 | Atlético Palmaflor | - | The Strongest | 0:0 | ||||
| 21. Journée | 27.09.2021 | The Strongest | - | Always Ready | 1:1 | ||||
| 22. Journée | 19.10.2021 | Royal Pari | - | The Strongest | 0:1 | ||||
| 23. Journée | 23.10.2021 | The Strongest | - | Real Potosí | 1:0 | ||||
| 24. Journée | 26.10.2021 | CD Guabirá | - | The Strongest | 0:0 | |
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| 25. Journée | 30.10.2021 | The Strongest | - | Blooming | 2:1 | ||||
| 26. Journée | 21.11.2021 | Bolívar | - | The Strongest | 0:1 | ||||
| 27. Journée | 26.11.2021 | The Strongest | - | Club Aurora | 3:0 | ||||
| 28. Journée | 03.12.2021 | Real Tomayapo | - | The Strongest | 0:0 | ||||
| 29. Journée | 05.12.2021 | The Strongest | - | Club San José | 2:0 | ||||
| 30. Journée | 12.12.2021 | Real Santa Cruz | - | The Strongest | 1:0 | |
Paraguay