| 1. Journée | 01.02.2025 | Defensor Sporting | - | Boston River | 2:0 |  |
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| 2. Journée | 08.02.2025 | River Plate | - | Defensor Sporting | 0:1 | |
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| 3. Journée | 16.02.2025 | Defensor Sporting | - | Racing | 2:0 |  |
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| 5. Journée | 07.03.2025 | Defensor Sporting | - | Liverpool | 0:1 | ||||
| 6. Journée | 16.03.2025 | Juventud de Las Piedras | - | Defensor Sporting | 2:1 | ||||
| 7. Journée | 23.03.2025 | Defensor Sporting | - | Cerro Largo | 0:0 | ||||
| 8. Journée | 27.03.2025 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 9. Journée | 01.04.2025 | Defensor Sporting | - | Miramar Misiones | 2:0 | ||||
| 10. Journée | 07.04.2025 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | ||||
| 11. Journée | 14.04.2025 | Defensor Sporting | - | CA Cerro | 3:2 | ||||
| 12. Journée | 21.04.2025 | Defensor Sporting | - | Progreso | 1:2 |
Uruguay