| 1. Journée | 12.09.2021 | Boston River | - | Montevideo Wanderers | 1:3 | ||||
| 2. Journée | 17.09.2021 | Rentistas | - | Boston River | 1:2 |  |
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| 3. Journée | 26.09.2021 | Boston River | - | Peñarol | 2:5 |  |
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| 4. Journée | 03.10.2021 | Montevideo City Torque | - | Boston River | 4:3 | ||||
| 5. Journée | 10.10.2021 | Boston River | - | Villa Española | 1:0 | ||||
| 6. Journée | 16.10.2021 | Nacional | - | Boston River | 3:2 | ||||
| 7. Journée | 21.10.2021 | Boston River | - | Cerrito | 3:2 | ||||
| 12. Journée | 14.11.2021 | Sud América | - | Boston River | 1:2 | ||||
| 15. Journée | 04.12.2021 | Boston River | - | Deportivo Maldonado | 2:1 |
Uruguay