| 3. Journée | 29.05.2022 | Rio Grande Valley FC | - | San Antonio FC | 2:3 |  |
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| 4. Journée | 02.06.2022 | Atlanta United II | - | Rio Grande Valley FC | 3:4 |  |
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| 4. Journée | 05.06.2022 | Rio Grande Valley FC | - | Los Angeles Galaxy II | 0:1 | ||||
| 4. Journée | 12.06.2022 | Oakland Roots | - | Rio Grande Valley FC | 2:2 | ||||
| 4. Journée | 19.06.2022 | Rio Grande Valley FC | - | Pittsburgh Riverhounds | 1:0 | ||||
| 4. Journée | 30.06.2022 | Rio Grande Valley FC | - | El Paso Locomotive | 0:0 | |
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| 5. Journée | 07.07.2022 | New Mexico United | - | Rio Grande Valley FC | 1:0 | ||||
| 5. Journée | 10.07.2022 | New Mexico United | - | Rio Grande Valley FC | 1:1 | ||||
| 5. Journée | 18.07.2022 | Rio Grande Valley FC | - | Las Vegas Lights FC | 0:1 | ||||
| 6. Journée | 07.08.2022 | Sacramento Republic | - | Rio Grande Valley FC | 1:1 |
Mexique