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| 04.11.2011 | 20:30 | Bridgend Town | - | Tata Steel | 5:3 ap | |
| 05.11.2011 | 15:00 | AFC Porth | - | Pontardawe Town | 3:0 | |
| 15:00 | Bryntirion Athletic | - | Goytre AFC | 5:2 | ||
| 15:00 | Builth Wells | - | Taff's Well AFC | 0:5 | ||
| 15:00 | Caerau Ely AFC | - | Goytre United | 1:8 | ||
| 15:00 | Caerleon AFC | - | Merthyr Saints | 3:4 | ||
| 15:00 | West End FC | - | Cardiff Corinthians | 2:1 | ||
| 15:00 | Newport Civil Service | - | Newbridge-on-Wye FC | 2:0 | ||
| 15:00 | Cambrian & Clydach | - | Llandrindod Wells FC | 2:0 | ||
| 15:00 | Barmouth & Dyffryn United | - | Caersws FC | 0:3 | ||
| 15:00 | Buckley Town | - | Holyhead Hotspur | 5:2 | ||
| 15:00 | Cefn Druids | - | Coedpoeth United | 8:0 | ||
| 15:00 | Denbigh Town | - | Flint Town United | 1:2 ap | ||
| 15:00 | Guilsfield FC | - | Llandudno FC | 1:3 | ||
| 15:00 | Llanidloes Town FC | - | GAP Connah's Quay FC | 0:2 | ||
| 15:00 | Montgomery Town | - | FC Cefn | 3:7 | ||
| 15:00 | Porthmadog FC | - | Rhyl FC | 2:3 | ||
| 15:30 | Haverfordwest County | - | Barry Town FC | 1:2 ap |
