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| Classement | équipe recevante | à l'extérieur | Premier tour | Second tour | » 1. Mi-temps | 2. Mi-temps |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Columbus Crew (M) | 34 | 15 | 12 | 7 | 25:14 | 11 | 57 |
| 2 |
|
Inter Miami CF | 34 | 13 | 14 | 7 | 33:24 | 9 | 53 |
| 3 |
|
New York City FC | 34 | 13 | 13 | 8 | 30:19 | 11 | 52 |
| 4 |
|
New York RB | 34 | 13 | 13 | 8 | 21:21 | 0 | 52 |
| 5 |
|
Philadelphia Union | 34 | 13 | 10 | 11 | 28:23 | 5 | 49 |
| 6 |
|
Nashville SC | 34 | 13 | 9 | 12 | 20:27 | -7 | 48 |
| 7 |
|
Charlotte FC | 34 | 8 | 20 | 6 | 19:16 | 3 | 44 |
| 8 |
|
D.C. United | 34 | 11 | 10 | 13 | 27:32 | -5 | 43 |
| 9 |
|
Toronto FC | 34 | 10 | 13 | 11 | 17:16 | 1 | 43 |
| 10 |
|
Orlando City | 34 | 11 | 9 | 14 | 25:25 | 0 | 42 |
| 11 |
|
FC Cincinnati | 34 | 8 | 16 | 10 | 20:22 | -2 | 40 |
| 12 |
|
New England Revolution | 34 | 9 | 12 | 13 | 22:27 | -5 | 39 |
| 13 |
|
CF Montréal | 34 | 9 | 12 | 13 | 22:31 | -9 | 39 |
| 14 |
|
Atlanta United FC | 34 | 7 | 17 | 10 | 15:18 | -3 | 38 |
| 15 |
|
Chicago Fire | 34 | 4 | 13 | 17 | 11:31 | -20 | 25 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Los Angeles FC | 34 | 16 | 7 | 11 | 30:18 | 12 | 55 |
| 2 |
|
Seattle Sounders | 34 | 14 | 12 | 8 | 23:16 | 7 | 54 |
| 3 |
|
Houston Dynamo | 34 | 12 | 16 | 6 | 20:11 | 9 | 52 |
| 4 |
|
Real Salt Lake | 34 | 12 | 14 | 8 | 30:19 | 11 | 50 |
| 5 |
|
Minnesota United FC | 34 | 13 | 9 | 12 | 25:24 | 1 | 48 |
| 6 |
|
St. Louis City SC | 34 | 12 | 11 | 11 | 26:23 | 3 | 47 |
| 7 |
|
Colorado Rapids | 34 | 11 | 13 | 10 | 26:28 | -2 | 46 |
| 8 |
|
Portland Timbers | 34 | 12 | 9 | 13 | 27:28 | -1 | 45 |
| 9 |
|
Los Angeles Galaxy | 34 | 11 | 11 | 12 | 22:26 | -4 | 44 |
| 10 |
|
Vancouver Whitecaps | 34 | 11 | 10 | 13 | 21:24 | -3 | 43 |
| 11 |
|
FC Dallas | 34 | 8 | 17 | 9 | 23:23 | 0 | 41 |
| 12 |
|
Austin FC | 34 | 8 | 15 | 11 | 15:21 | -6 | 39 |
| 13 |
|
Sporting Kansas City | 34 | 8 | 11 | 15 | 19:27 | -8 | 35 |
| 14 |
|
San Jose Earthquakes | 34 | 7 | 14 | 13 | 21:29 | -8 | 35 |
| Play-off | |
| Play-off |
