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| 21.09.2021 | 16:00 | MFK Mikolaiv | - | Rukh Lviv | 0:3 (0:2) | |
| 18:00 | Metalist Kharkiv | - | Desna Chernigov | 2:1 (0:1) | ||
| 22.09.2021 | 12:00 | Tavriya Simferopol | - | FK Oleksandriya | 1:3 (1:2) | |
| 14:00 | FC LNZ Cherkasy | - | Inhulets Petrove | 2:1 (1:1) | ||
| 16:00 | Volyn Lutsk | - | FK Mariupol | 5:6 (0:0, 0:0, 0:0) tab | ||
| 16:00 | FK VPK-Ahro Shevchenkivka | - | SK Dnipro-1 | 1:2 (0:1) | ||
| 18:00 | FK Obolon | - | NK Veres | 0:1 (0:0) | ||
| 23.09.2021 | 12:00 | Epitsentr Dunaivtsi | - | Metalist 1925 Kharkiv | 0:1 (0:0) | |
| 14:00 | Hirnyk-Sport | - | FK Lviv | 0:2 (0:2) | ||
| 16:00 | Prykarpattya Ivano-Frankivsk | - | Chernomorets Odessa | 1:4 (0:2) | ||
| 18:00 | Alians Lypova Dolyna | - | FC Mynai | 3:2 (2:2) |
