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| 02.12.2020 | 12:00 | SK Dnipro-1 | - | FK VPK-Ahro Shevchenkivka | 5:0 (1:0) | |
| 12:00 | NK Veres | - | FK Mariupol | 1:0 (0:0) | ||
| 12:00 | FK Nyva Vinnytsia | - | Kolos Kovalivka | 0:4 (0:1) | ||
| 13:00 | Ahrobiznes Volochysk | - | Vorskla Poltava | 1:0 (1:0) | ||
| 15:30 | FK Oleksandriya | - | FC Mynai | 3:0 (1:0) | ||
| 16.12.2020 | 13:00 | Desna Chernigov | - | Zorya Lugansk | 0:1 (0:1) |
