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| H (Match allé) | Bayburt İl Özel İdare | - | 1461 Trabzon FK | 0:0 (0:0) | ||
| R (match retour) | 1461 Trabzon FK | - | Bayburt İl Özel İdare | 0:2 (0:0) | ||
| H (Match allé): 12.05.2022 15:00 | R (match retour): 16.05.2022 14:30 | vainqueur: Bayburt İl Özel İdare | ||||
| H (Match allé) | Sivas Belediyespor | - | Bodrumspor | 0:0 (0:0) | ||
| R (match retour) | Bodrumspor | - | Sivas Belediyespor | 1:0 (0:0) | ||
| H (Match allé): 12.05.2022 15:00 | R (match retour): 16.05.2022 15:00 | vainqueur: Bodrumspor | ||||
| H (Match allé) | Tarsus Idman Yurdu | - | Amed SK | 0:0 (0:0) | ||
| R (match retour) | Amed SK | - | Tarsus Idman Yurdu | 6:7 (0:0, 0:0, 0:0) tab | ||
| H (Match allé): 12.05.2022 19:00 | R (match retour): 16.05.2022 19:00 | vainqueur: Tarsus Idman Yurdu | ||||
| H (Match allé) | Isparta 32 SK | - | Karacabey Belediyespor | 0:2 (0:1) | ||
| R (match retour) | Karacabey Belediyespor | - | Isparta 32 SK | 2:1 (0:1) | ||
| H (Match allé): 12.05.2022 19:00 | R (match retour): 16.05.2022 19:00 | vainqueur: Karacabey Belediyespor | ||||
