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| 08.09.2021 | 16:00 | Sloga Požega | - | FK Kabel | 4:1 | |
| 16:00 | FK Mokra Gora | - | Budućnost Dobanovci | 7:8 tab | ||
| 16:00 | SFS Borac Paraćin | - | FK Žarkovo | 0:2 | ||
| 16:00 | Radnički Beograd | - | Sloga Kraljevo | 3:1 | ||
| 16:00 | Jedinstvo Rumenka | - | FK Loznica | 0:3 | ||
| 16:00 | FK Trayal | - | FK Grafičar | 1:0 | ||
| 16:00 | Železničar Pančevo | - | Radnički Pirot | 3:0 | ||
| 16:00 | Radnički (SM) | - | FK Kolubara | 0:1 | ||
| 16:00 | FK Zemun | - | Dinamo Vranje | 0:1 | ||
| 16:00 | Dubočica Leskovac | - | IMT Beograd | 1:0 | ||
| 18:00 | Borac Čačak | - | FK Jagodina | 2:4 tab |
