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| 26.10.2021 | 14:00 | CSO Filiaşi | - | FC Hermannstadt | 4:3 (1:1, 1:1, 2:2) tab | |
| 17:00 | Gaz Metan Mediaş | - | Chindia Târgoviște | 0:1 (0:1) | ||
| 20:00 | Dinamo Bucureşti | - | Argeș Pitești | 1:2 (0:0) | ||
| 27.10.2021 | 03:00 | FC Voluntari | - | FCSB | ||
| 17:00 | Minaur Baia Mare | - | CS Universitatea Craiova | 0:4 (0:2) | ||
| 28.10.2021 | 14:00 | FC Buzău | - | FC Dunărea Călărași | 3:0 (1:0) | |
| 17:00 | FC Universitatea Craiova | - | Sepsi OSK | 0:1 (0:1) | ||
| 20:00 | SSU Poli Timişoara | - | Rapid Bucureşti | 2:0 (1:0) |
