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| 27.10.2021 | 14:00 | FK Jezero | - | FK Budućnost Podgorica | 1:3 | |
| 14:00 | FK KOM Podgorica | - | FK Iskra Danilovgrad | 0:1 | ||
| 14:00 | FK Rudar Pljevlja | - | FK Arsenal | 3:0 | ||
| 14:00 | FK Bokelj | - | FK Sutjeska | 1:2 | ||
| 14:00 | FK Dečić Tuzi | - | OFK Petrovac | 2:0 | ||
| 14:00 | OSK Igalo | - | FK Mornar | 4:3 tab | ||
| 14:00 | FK Podgorica | - | FK Zeta | 2:0 | ||
| 14:00 | OFK Titograd | - | Jedinstvo Bijelo Polje | 1:0 |
