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| H (Match allé) | Santos Laguna | - | Deportivo Toluca | 1:0 (0:0) | ||
| R (match retour) | Deportivo Toluca | - | Santos Laguna | 4:0 (2:0) | ||
| H (Match allé): 30.04.2025 19:00 | R (match retour): 03.05.2025 17:00 | vainqueur: Deportivo Toluca | ||||
| H (Match allé) | CF Pachuca | - | FC Juárez | 2:1 (1:0) | ||
| R (match retour) | FC Juárez | - | CF Pachuca | 2:1 (1:0) | ||
| H (Match allé): 01.05.2025 17:15 | R (match retour): 05.05.2025 02:00 | |||||
