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| H (Match allé) | Pumas UNAM | - | Atlas Guadalajara | 4:0 (3:0) | ||
| R (match retour) | Atlas Guadalajara | - | Pumas UNAM | 1:1 (0:0) | ||
| H (Match allé): 20.10.2022 17:00 | R (match retour): 23.10.2022 16:00 | vainqueur: Pumas UNAM | ||||
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| H (Match allé) | Pumas UNAM | - | Atlas Guadalajara | 4:0 (3:0) | ||
| R (match retour) | Atlas Guadalajara | - | Pumas UNAM | 1:1 (0:0) | ||
| H (Match allé): 20.10.2022 17:00 | R (match retour): 23.10.2022 16:00 | vainqueur: Pumas UNAM | ||||
