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| H (Match allé) | Deportivo Toluca | - | CF Pachuca | 0:2 (0:1) | ||
| R (match retour) | CF Pachuca | - | Deportivo Toluca | 0:2 (0:0) | ||
| H (Match allé): 12.05.2021 16:00 | R (match retour): 15.05.2021 17:00 | |||||
| H (Match allé) | Atlas Guadalajara | - | CF Monterrey | 1:2 (1:0) | ||
| R (match retour) | CF Monterrey | - | Atlas Guadalajara | 1:0 (0:0) | ||
| H (Match allé): 13.05.2021 16:00 | R (match retour): 16.05.2021 16:00 | vainqueur: CF Monterrey | ||||
