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| H (Match allé) | Atlas Guadalajara | - | CF Monterrey | 0:0 (0:0) | ||
| R (match retour) | CF Monterrey | - | Atlas Guadalajara | 1:1 (0:0) | ||
| H (Match allé): 25.11.2020 16:00 | R (match retour): 28.11.2020 16:00 | vainqueur: Atlas Guadalajara | ||||
| H (Match allé) | Cruz Azul | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| R (match retour) | Deportivo Guadalajara | - | Cruz Azul | 5:1 (1:1) | ||
| H (Match allé): 26.11.2020 18:00 | R (match retour): 29.11.2020 16:00 | vainqueur: Deportivo Guadalajara | ||||
