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| H (Match allé) | Santos Laguna | - | Atlas Guadalajara | 0:1 (0:1) | ||
| R (match retour) | Atlas Guadalajara | - | Santos Laguna | 3:1 (1:0) | ||
| H (Match allé): 19.05.2022 02:00 | R (match retour): 21.05.2022 16:00 | vainqueur: Atlas Guadalajara | ||||
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| H (Match allé) | Santos Laguna | - | Atlas Guadalajara | 0:1 (0:1) | ||
| R (match retour) | Atlas Guadalajara | - | Santos Laguna | 3:1 (1:0) | ||
| H (Match allé): 19.05.2022 02:00 | R (match retour): 21.05.2022 16:00 | vainqueur: Atlas Guadalajara | ||||
