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| H (Match allé) | Cruz Azul | - | Pumas UNAM | 0:0 (0:0) | ||
| R (match retour) | Pumas UNAM | - | Cruz Azul | 1:3 (1:1) | ||
| H (Match allé): 23.11.2008 00:00 | R (match retour): 01.12.2008 00:00 | vainqueur: Cruz Azul | ||||
| H (Match allé) | UANL Tigres | - | Atlante | 1:1 (1:0) | ||
| R (match retour) | Atlante | - | UANL Tigres | 1:1 (1:0) | ||
| H (Match allé): 23.11.2008 02:00 | R (match retour): 30.11.2008 04:00 | |||||
| H (Match allé) | UAG Tecos | - | Deportivo Toluca | 0:0 (0:0) | ||
| R (match retour) | Deportivo Toluca | - | UAG Tecos | 2:0 (0:0) | ||
| H (Match allé): 23.11.2008 22:00 | R (match retour): 30.11.2008 19:00 | vainqueur: Deportivo Toluca | ||||
| H (Match allé) | Santos Laguna | - | Club San Luis | 3:1 (2:1) | ||
| R (match retour) | Club San Luis | - | Santos Laguna | 1:2 (1:0) | ||
| H (Match allé): 24.11.2008 00:00 | R (match retour): 30.11.2008 02:00 | vainqueur: Santos Laguna | ||||
