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| H (Match allé) | Club Irapuato | - | Inter Playa | 0:0 (0:0) | ||
| R (match retour) | Inter Playa | - | Club Irapuato | 1:2 (1:1) | ||
| H (Match allé): 30.04.2021 03:00 | R (match retour): 02.05.2021 23:00 | vainqueur: Club Irapuato | ||||
| H (Match allé) | Alacranes de Durango | - | Cruz Azul Hidalgo | 1:1 (1:1) | ||
| R (match retour) | Cruz Azul Hidalgo | - | Alacranes de Durango | 1:1 (1:1) | ||
| H (Match allé): 30.04.2021 03:30 | R (match retour): 02.05.2021 23:00 | |||||
