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| H (Match allé) | Dorados de Sinaloa | - | Club Irapuato | 0:0 (0:0) | ||
| R (match retour) | Club Irapuato | - | Dorados de Sinaloa | 1:1 (0:1) | ||
| H (Match allé): 28.04.2011 04:00 | R (match retour): 01.05.2011 03:00 | vainqueur: Dorados de Sinaloa | ||||
| H (Match allé) | Cruz Azul Hidalgo | - | Club Tijuana | 2:2 (0:1) | ||
| R (match retour) | Club Tijuana | - | Cruz Azul Hidalgo | 5:1 (4:0) | ||
| H (Match allé): 28.04.2011 23:00 | R (match retour): 01.05.2011 22:00 | vainqueur: Club Tijuana | ||||
| H (Match allé) | Correcaminos UAT | - | Atlante UTN | 1:1 (0:0) | ||
| R (match retour) | Atlante UTN | - | Correcaminos UAT | 1:0 (1:0) | ||
| H (Match allé): 29.04.2011 03:30 | R (match retour): 01.05.2011 19:00 | vainqueur: Atlante UTN | ||||
