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| H (Match allé) | Deportivo Guadalajara | - | Pumas UNAM | 3:2 (1:0) | ||
| R (match retour) | Pumas UNAM | - | Deportivo Guadalajara | 1:1 (0:1) | ||
| H (Match allé): 10.11.2022 17:00 | R (match retour): 14.11.2022 00:00 | vainqueur: Deportivo Guadalajara | ||||
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| H (Match allé) | Deportivo Guadalajara | - | Pumas UNAM | 3:2 (1:0) | ||
| R (match retour) | Pumas UNAM | - | Deportivo Guadalajara | 1:1 (0:1) | ||
| H (Match allé): 10.11.2022 17:00 | R (match retour): 14.11.2022 00:00 | vainqueur: Deportivo Guadalajara | ||||
