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| 18.10.2022 | 12:00 | FC Iskra-Stal | - | Dacia Buiucani | 0:7 | |
| 12:00 | Locomotiva Ocnița | - | FC Milsami | 0:2 | ||
| 12:00 | La Familia Bender | - | FC Sfîntul Gheorghe | 0:5 | ||
| 12:00 | Dinamo-Auto | - | Univer-Oguzsport | 0:2 ap | ||
| 19.10.2022 | 12:00 | FC Floreşti | - | CS Petrocub | 2:4 tab | |
| 12:00 | Speranța Drochia | - | FC Sheriff | 0:6 | ||
| 15:00 | FC Zimbru | - | Victoria Bardar | 3:0 | ||
| 16:00 | FC Bălţi | - | FC Stăuceni | 4:0 |
