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| 17.05.2022 | 17:00 | Tauras Tauragė | - | Marijampolė City | 1:4 | |
| 18.05.2022 | 17:00 | DFK Dainava | - | FK Panevėžys | 0:2 | |
| 17:00 | Neptūnas Klaipėda | - | FK Žalgiris | 0:1 | ||
| 24.05.2022 | 17:00 | Granitas Vilnius | - | Kauno Žalgiris | 0:4 | |
| 18:45 | FK Ataka | - | FK Riteriai | 1:5 | ||
| 25.05.2022 | 13:00 | Baltijos FA | - | FC Hegelmann | 0:6 | |
| 18:00 | FK Sūduva | - | Banga Gargždai | 2:0 | ||
| 18:00 | FK TransINVEST | - | FK Jonava | 1:2 |
