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| H (Match allé) | Victoria | - | Motagua | 0:0 (0:0) | ||
| R (match retour) | Motagua | - | Victoria | 2:1 (1:0) | ||
| H (Match allé): 01.12.2022 02:30 | R (match retour): 03.12.2022 23:30 | vainqueur: Motagua | ||||
| H (Match allé) | Marathón | - | Olimpia | 1:3 (1:1) | ||
| R (match retour) | Olimpia | - | Marathón | 1:3 (1:2) | ||
| H (Match allé): 01.12.2022 22:05 | R (match retour): 05.12.2022 01:00 | |||||
