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| H (Match allé) | Vida | - | Motagua | 1:0 (0:0) | ||
| R (match retour) | Motagua | - | Vida | 3:2 (1:0) | ||
| H (Match allé): 28.04.2011 03:30 | R (match retour): 01.05.2011 03:30 | vainqueur: Vida | ||||
| H (Match allé) | Marathón | - | Olimpia | 1:0 (1:0) | ||
| R (match retour) | Olimpia | - | Marathón | 1:0 (0:0) | ||
| H (Match allé): 29.04.2011 03:30 | R (match retour): 02.05.2011 01:00 | |||||
