 |
 |
| 15.05.2021 | 12:00 | UD SS Reyes | - | Algeciras CF | 1:3 (1:1) | |
| 18:00 | Burgos CF | - | CD Calahorra | 1:0 (0:0) ap | ||
| 20:00 | Real Sociedad B | - | FC Andorra | 2:1 (1:1) ap | ||
| 20:00 | Linares Deportivo | - | SD Amorebieta | 1:2 (0:1) | ||
| 16.05.2021 | 12:00 | UD Ibiza | - | Real Madrid Castilla | 0:0 (0:0, 0:0) ap | |
| 12:00 | UCAM Murcia CF | - | FC Barcelona B | 5:4 (1:0, 2:2, 2:2) tab | ||
| 20:15 | CD Badajoz | - | Zamora CF | 2:0 (2:0) | ||
| 20:15 | Athletic Club B | - | RC Celta B | 2:1 (0:0) |
