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| H (Match allé) | SFC Opava | - | Bohemians Praha 1905 | 0:1 (0:1) | ||
| R (match retour) | Bohemians Praha 1905 | - | SFC Opava | 2:0 (1:0) | ||
| H (Match allé): 19.05.2022 17:00 | R (match retour): 22.05.2022 16:00 | vainqueur: Bohemians Praha 1905 | ||||
| H (Match allé) | FK Teplice | - | FC Sellier & Bellot Vlašim | 3:0 (1:0) | ||
| R (match retour) | FC Sellier & Bellot Vlašim | - | FK Teplice | 2:2 (2:1) | ||
| H (Match allé): 19.05.2022 17:00 | R (match retour): 22.05.2022 16:00 | vainqueur: FK Teplice | ||||
