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| H (Match allé) | AEK Larnaca | - | Ethnikos Achna | 1:2 (1:1) | ||
| R (match retour) | Ethnikos Achna | - | AEK Larnaca | 3:1 (0:1) | ||
| H (Match allé): 26.04.2022 17:00 | R (match retour): 04.05.2022 18:00 | vainqueur: Ethnikos Achna | ||||
| H (Match allé) | Anorthosis Famagusta | - | Omonia Nikosia | 0:2 (0:2) | ||
| R (match retour) | Omonia Nikosia | - | Anorthosis Famagusta | 1:1 (1:1) | ||
| H (Match allé): 26.04.2022 18:00 | R (match retour): 04.05.2022 18:00 | vainqueur: Omonia Nikosia | ||||
